women with overweight

Weight loss may protect against endometrial cancer

Women with overweight and obesity, are at risk of developing endometrial cancer, significantly reduced the concentration of cancer biomarkers and markers of inflammation after surgical correction of weight. In 3 cases, after the operation was observed even restoring the normal functioning of the endometrium. This was reported by researchers at the conference of the American Association for Cancer Research buy xenical online (American Association for Cancer Research).

A study by researchers is especially important against the background of the obesity epidemic in the United States, resulted in the increase in cancer incidence. This may be due to the fact that chronic systemic inflammation which accompanies obesity, atypical can stimulate cell proliferation. Among cancers, depending on obesity, the most severe is a cancer of the endometrium. However, until now it has not been studied whether the reduction in weight can reduce the risk of developing the disease. To answer this question, Faina Linkov (Faina Linkov) from the University of Pittsburgh (University of Pittsburgh) and her colleagues compared the biopsy of the endometrium of patients with obesity prior to bariatric surgery and at 1 year after.

(For bariatric surgery include gastric banding, gastroplasty, and gastric bypass, liposuction and abdominoplasty are not bariatric surgery and weight loss goals do not apply - VM.)

The researchers assessed the number of receptors for estrogen, progesterone and androgens, the biomarker Ki-67 and activators of immune response CD3 and CD20.

59 patients participated in the study, their average age was 42 years, the average weight - 127 kg, mean body mass index - 46,8. After 1 year after bariatric surgery on the background of significant weight loss in all patients significantly decreased expression of hormone receptors and CD20-cells and significantly less - production of CD3 cells and biomarker Ki-67. Moreover, prior to the operation in four women have endometrial hyperplasia cells. After 1 year after the operation ceased hyperplasia was diagnosed in two patients, and 2 years after surgery - in three.

Linkov and her colleagues conducted another study, which was attended by 68 obese patients (18 of them men) who are using various techniques to reduce its weight. During one year of observation average weight of participants decreased from 105 to 78 kg, and body mass index - from 33 to 27-28. Results for serum analysis before and after the participants showed a significant reduction in weight loss concentration of C-reactive protein, C-peptide, insulin-like growth factor 2, insulin, plasminogen activator inhibitor and soluble E-selectin. All these substances maintain the chronic inflammation and can provoke the development of cancer. Therefore, the study authors call gynecologists-oncologists and Bariatric Surgeons to work closely.